Role of central melanocortin pathways in energy homeostasis

被引:104
作者
Garfield, Alastair S. [1 ]
Lam, Daniel D. [1 ]
Marston, Oliver J. [1 ]
Przydzial, Magdalena J. [1 ]
Heisler, Lora K. [1 ]
机构
[1] Univ Cambridge, Dept Pharmacol, Cambridge CB2 1PD, England
关键词
AGOUTI-RELATED PROTEIN; MELANIN-CONCENTRATING HORMONE; PROOPIOMELANOCORTIN-DEFICIENT MICE; MELANOCYTE-STIMULATING HORMONE; HYPOTHALAMIC ARCUATE NUCLEUS; ANOREXIGENIC POMC NEURONS; RECEPTOR MESSENGER-RNA; BROWN ADIPOSE-TISSUE; CAUDAL BRAIN-STEM; HIGH-FAT DIET;
D O I
10.1016/j.tem.2009.02.002
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The rise in the global prevalence of human obesity has emphasized the need for a greater understanding of the physiological mechanisms that underlie energy homeostasis. Numerous circulating nutritional cues and central neuromodulatory signals are integrated within the brain to regulate both short- and long-term nutritional state. The central melanocortin system represents a crucial point of convergence for these signals and, thus, has a fundamental role in regulating body weight. The melanocortin ligands, synthesized in discrete neuronal populations within the hypothalamus and brainstem, modulate downstream homeostatic signalling via their action at central melanocortin-3 and -4 receptors. Intimately involved in both ingestive behaviour and energy expenditure, the melanocortin system has garnered much interest as a potential therapeutic target for human obesity.
引用
收藏
页码:203 / 215
页数:13
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