Properties of an oxygen-sensitive mutant mev-3 of the nematode Caenorhabditis elegans

被引：12

作者：

Yamamoto, K

Honda, S

Ishii, N

机构：

[1] TOKAI UNIV,SCH MED,DEPT MOL LIFE SCI,ISEHARA,KANAGAWA 25911,JAPAN

[2] TOKYO METROPOLITAN INST GERONTOL,ISOTOPE LAB,ITABASHI KU,TOKYO 173,JAPAN

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 1996年 / 358卷 / 01期

关键词：

C-elegans; oxygen-sensitive mutant; methyl viologen; development; life span;

D O I：

10.1016/0027-5107(96)00070-X

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A spontaneous mutant of meu-3 of the nematode Caenorhabditis elegans was isolated on the basis of its resistance to methyl viologen, which generates superoxide radicals. Contrary to expectation, the mutant proved hypersensitive to oxygen. Oxygen retarded development and reduced fecundity in a concentration-dependent fashion in meu-3 but not in wild-type. In addition, the mean life span of meu-3 (but not wild-type) was progressively shortened when animals were incubated under 70% oxygen.

引用

页码：1 / 6

页数：6

共 21 条

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[2]

BRENNER S, 1974, GENETICS, V77, P71

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