REM sleep behavior disorder in Parkinson's disease and dementia with Lewy bodies

被引:126
作者
Boeve, BF
Silber, MH
Ferman, TJ
机构
[1] Mayo Clin, Coll Med, Sleep Disorders Ctr, Rochester, MN 55905 USA
[2] Mayo Clin, Coll Med, Dept Neurol, Rochester, MN 55905 USA
[3] Mayo Clin, Coll Med, Dept Psychiat & Psychol, Jacksonville, FL 32224 USA
关键词
REM sleep behavior disorder; Parkinson's disease; dementia with Lewy bodies; synuclein; synucleinopathy;
D O I
10.1177/0891988704267465
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia manifested by vivid, often frightening dreams associated with simple or complex motor behavior during REM sleep. Patients appear to "act out their dreams," in which the exhibited behaviors mirror the content of the dreams. Management of RBD involves counseling about safety measures in the sleep environment; in those at risk for injury, clonazepam and/or melatonin is usually effective. In this article, the authors present a detailed review of the clinical and polysomnographic features, differential diagnosis, diagnostic criteria, management strategies, and pathophysiologic mechanisms of RBD. They then review the literature and their institutional experience of RBD associated with neurodegenerative disease, particularly Parkinson's disease and dementia with Lewy bodies. The evolving data suggests that RBD may have clinical diagnostic and pathophysiologic significance in isolation and when associated with neurodegenerative disease.
引用
收藏
页码:146 / 157
页数:12
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