Routine HLA-B genotyping with PCR-sequence-specific oligonucleotides (PCR-SSO) detects eight new alleles: B0807, B0809, B1551, B3529, B3532, B4025, B5304 and B5508

被引：7

作者：

Kennedy, CT ^{[1
]}

Dodd, R ^{[1
]}

Le, T ^{[1
]}

Wallace, R ^{[1
]}

Ng, G ^{[1
]}

Greville, WD ^{[1
]}

Kennedy, A ^{[1
]}

Taverniti, A ^{[1
]}

Moses, JH ^{[1
]}

Clow, N ^{[1
]}

Watson, N ^{[1
]}

Dunckley, H ^{[1
]}

机构：

[1] Australian Red Cross Blood Serv, Mol Genet Lab, Sydney, NSW 2000, Australia

来源：

TISSUE ANTIGENS | 2000年 / 55卷 / 03期

关键词：

HLA-B*0807; HLA-B*0809; HLA-B*1551; HLA-B*3529; HLA-B*3532; HLA-B*4025; HLA-B*5304; HLA-B*5508; oligotyping;

D O I：

10.1034/j.1399-0039.2000.550311.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This paper describes eight new alleles (B*0807, B*0809, B*1551, B*3529, B*3532, B*4025, B*5304 and B*5508) that have been found by routine HLA-B genotyping with sequence specific oligonucleotides (SSOs). All of the new alleles have variations which cause changes in residues that occur within antigen binding pockets and T-cell recognition sites of the antigen. The new polymorphisms within these new alleles may affect the nature and specificity of peptide binding and cause differential T-cell activation, which may have an affect in transplantation.

引用

页码：266 / 270

页数：5

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Routine HLA-B genotyping with PCR-sequence-specific oligonucleotides (PCR-SSO) detects eight new alleles: B*0807, B*0809, B*1551, B*3529, B*3532, B*4025, B*5304 and B*5508

Routine HLA-B genotyping with PCR-sequence-specific oligonucleotides (PCR-SSO) detects eight new alleles: B0807, B0809, B1551, B3529, B3532, B4025, B5304 and B5508