Effects of Uremic Toxins on Vascular and Bone Remodeling

被引：16

作者：

Barreto, Fellype C. ^{[2
,3
]}

Barreto, Daniela V. ^{[2
,3
]}

Liabeuf, Sophie ^{[2
,3
]}

Drueeke, Tilman B. ^{[4
]}

Massy, Ziad A. ^{[1
,2
,3
,5
,6
]}

机构：

[1] Amiens Univ Hosp, Div Clin Pharmacol & Nephrol, INSERM, ERI 12, F-80054 Amiens, France

[2] Amiens Univ Hosp, Clin Res Ctr, F-80054 Amiens, France

[3] Jules Verne Univ Picardy, Amiens, France

[4] Hop Necker Enfants Malad, INSERM, U845, Paris, France

[5] Amiens Univ Hosp, Div Clin Pharmacol, F-80054 Amiens, France

[6] Amiens Univ Hosp, Div Nephrol, F-80054 Amiens, France

来源：

SEMINARS IN DIALYSIS | 2009年 / 22卷 / 04期

关键词：

OSTEOCLAST-LIKE CELLS; LOW-TURNOVER BONE; PARATHYROID-HORMONE; RENAL-FAILURE; PHOSPHATE CONCENTRATION; HEMODIALYSIS-PATIENTS; AORTIC CALCIFICATION; SKELETAL RESISTANCE; DEFICIENT MICE; LEPTIN;

D O I：

10.1111/j.1525-139X.2009.00595.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Chronic kidney disease (CKD) is associated with both extensive vascular calcification and abnormal bone remodeling, namely renal osteodystrophy. Moreover, there is increasing evidence for a close relationship between bone and vessel function. Pathological vascular calcification has been recently recognized as an active, cell-mediated process with similarities to physiological skeletal mineralization. Accordingly, we described the concept of vascular remodeling, in analogy to bone remodeling. In this review, we discuss the role of uremic toxins in the cross-talk between bone and vessel, and emphasize their potential contribution to the development of both vascular and bone remodeling disorders in patients with CKD.

引用

页码：433 / 437

页数：5

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