Antidepressant therapy can improve adherence to antiretroviral regimens among HIV-infected and depressed patients

被引：35

作者：

Dalessandro, Margherita

Conti, Chiara M.

Gambi, Francesco

Falasca, Katia

Doyle, Robert

Conti, Pio

Caciagli, Francesco

Fulcheri, Mario

Vecchiet, Jacopo

机构：

[1] Univ G dAnnunzio, Clin Infect Dis, Chieti, Italy

[2] Univ G dAnnunzio, Div Immunol, Chieti, Italy

[3] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Boston, MA USA

[4] Univ G dAnnunzio, Div Pharmacol, Chieti, Italy

[5] Univ G dAnnunzio, Clin Psychol, Chieti, Italy

[6] Univ G dAnnunzio, Div Psychiat, Chieti, Italy

来源：

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY | 2007年 / 27卷 / 01期

关键词：

D O I：

10.1097/jcp.0b013e31802f0dd1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Several strategies have been introduced to manage nonadherence to highly active antiretroviral therapy (HAART). Treatment with antidepressants may improve self-reported adherence. In this brief report, a small sample of HIV-depressed patients (n = 9) were treated for a 6-month period with antidepressants improving self-reported adherence based on the HAART scale (poor, good, satisfactory, and optimal). Before the antidepressant treatment, adherence was reported as "good" by 3 patients and "satisfactory" by 6 patients. After antidepressant therapy, adherence to antiretroviral regimes was statistically higher in HIVdepressed on treatment than in HIV-depressed patients not treated with antidepressants (P < 0.0001). We used chi(2) test with a significance level at P < 0.05. Treating depression in HIV-infected patients may serve to improve adherence to HAART.

引用

页码：58 / 61

页数：4

共 27 条

[1] Depressive symptoms, neurocognitive impairment, and adherence to highly active antiretroviral therapy among HIV-infected persons [J].