Self-organisation in the assembly of gels from mixtures of different dendritic peptide building blocks

被引:88
作者
Hirst, Andrew R.
Huang, Buqing
Castelletto, Valeria
Hamley, Ian W.
Smith, David K. [1 ]
机构
[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England
[2] Univ Reading, Sch Chem, Reading RG6 6AD, Berks, England
基金
英国工程与自然科学研究理事会;
关键词
chirality; dendrimers; gels; nanotechnology; supramolecular chemistry;
D O I
10.1002/chem.200601665
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
This paper investigates dendritic peptides capable of assembling into nanostructured gels, and explores the effect on self-assembly of mixing different molecular building blocks. Thermal measurements, small angle Xray scattering (SAXS) and circular dichroism (CD) spectroscopy are used to probe these materials on macroscopic, nanoscopic and molecular length scales. The results from these investigations demonstrate that in this case, systems with different "size" and "chirality" factors can self-organise, whilst systems with different "shape" factors cannot. The "size" and "chirality" factors are directly connected with the molecular information programmed into the dendritic peptides, whilst the shape factor depends on the group linking these peptides together-this is consistent with molecular recognition hydrogen bond pathways between the peptidic building blocks controlling the ability of these systems to self-recognise. These results demonstrate that mixtures of relatively complex peptides, with only subtle differences on the molecular scale, can self-organise into nanoscale structures, an important step in the spontaneous assembly of ordered systems from complex mixtures.
引用
收藏
页码:2180 / 2188
页数:9
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