Peroxisome targeting signal 1: Is it really a simple tripeptide?

被引：217

作者：

Brocard, Cecile ^{[1
]}

Hartig, Andreas ^{[1
]}

机构：

[1] Univ Vienna, Dept Biochem, Max F Perutz Labs, A-1030 Vienna, Austria

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2006年 / 1763卷 / 12期

关键词：

PTS1; PEX5; targeting; peroxisome; predictor;

D O I：

10.1016/j.bbamcr.2006.08.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Originally.. the peroxisomal targeting signal 1 (PTS 1) was defined as a tripeptide at the C-terminus of proteins prone to be imported into the peroxisomal matrix. The corresponding receptor PEX5 initiates the translocation of proteins by identifying potential substrates via their C-termini and trapping PTS Is through remodeling of its TPR domain. Thorough studies on the interaction between PEX5 and PTS I as well as sequence-analytic tools revealed the influence of amino acid residues further upstream of the ultimate tripeptide. Altogether, PTS Is should be defined as dodecamer sequences at the C-terminal ends of proteins. These sequences accommodate physical contacts with both the surface and the binding cavity of PEX5 and ensure accessibility of the extreme C-terminus. Knowledge-based approaches in applied Bioinformatics provide reliable tools to accurately predict the peroxisomal location of proteins not yet determined experimentally. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：1565 / 1573

页数：9

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