Synthesis of 2-substituted-pyrrolidinethiourea derivatives and their antagonist effect on vanilloid receptor

被引：14

作者：

Park, HG ^{[1
]}

Park, MK

Choi, JY

Choi, SH

Lee, J

Suh, YG

Oh, U

Lee, J

Kim, HD

Park, YH

Jeong, YS

Choi, JK

Jew, SS

机构：

[1] Seoul Natl Univ, Pharmaceut Sci Res Inst, Seoul 151742, South Korea

[2] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

[3] Sookmyung Womens Univ, Coll Pharm, Seoul 140742, South Korea

[4] AmorePacific R&D Ctr, Youngin Si 449900, Kyounggi Do, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(02)00887-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four pyrrolidine derivatives were prepared by the formation of a 5-membered ring based on capsazepine. Among them, the two carbon extended derivatives, 4a (IC50 = 55 muM) and 4b (IC50 = 3 muM), both showed different levels of antagonist activity against the vanilloid receptor in a Ca-45(2+)-influx assay. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：197 / 200

页数：4

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