A Highly Active Catalyst for Huisgen 1,3-Dipolar Cycloadditions Based on the Tris(triazolyl)methanol-Cu(I) Structure

被引：202

作者：

Oezcubukcu, Salih ^{[1
]}

Ozkal, Erhan ^{[1
]}

Jimeno, Ciril ^{[1
]}

Pericas, Miquel A. ^{[1
,2
]}

机构：

[1] Inst Chem Res Catalonia ICIQ, Tarragona 43007, Spain

[2] Univ Barcelona, Dept Quim Organ, Barcelona 08080, Spain

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 20期

关键词：

AZIDE-ALKYNE CYCLOADDITION; CHIRAL LIGANDS; OPTIMIZATION; ADDITIONS; POLYMER; DESIGN; FAMILY; WATER;

D O I：

10.1021/ol9018776

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new tris(1-benzyl-1H-1,2,3-triazol-4-yl)methanol ligand 3 has been prepared by a triple Cu(I)-catalyzed alkyne-azide 1,3-dipolar cycloaddition (CuAAC). Ligand 3 forms a stable complex with CuCl, which catalyzes the Huisgen 1,3-dipolar cycloaddition on water or under neat conditions. Low catalyst loadings, short reaction times at room temperature, and compatibility with free amino groups make 3-CuCl an outstanding catalyst for CuAAC.

引用

页码：4680 / 4683

页数：4

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