Combinatorial glycosylation of glycopeptide antibiotics

被引：12

作者：

Baltz, RH ^{[1
]}

机构：

[1] Cubist Pharmaceut, Nat Prod Res, Lexington, MA 02421 USA

来源：

CHEMISTRY & BIOLOGY | 2002年 / 9卷 / 12期

关键词：

D O I：

10.1016/S1074-5521(02)00289-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The glycosyltransferases GtfE and GtfD from the vancomycin producer Amycolatopsis orientalis have promiscuous substrate and NDP-sugar specificities. They have been used to generate novel glycopeptide antibiotics containing the heptapeptide scaffolds of vancomycin and teichoplanin [1].

引用

页码：1268 / 1270

页数：3

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