Global Resting-State Functional Magnetic Resonance Imaging Analysis Identifies Frontal Cortex, Striatal, and Cerebellar Dysconnectivity in Obsessive-Compulsive Disorder

被引：244

作者：

Anticevic, Alan ^{[1
,5
,6
]}

Hu, Sien ^{[1
]}

Zhang, Sheng ^{[1
]}

Savic, Aleksandar ^{[1
,8
]}

Billingslea, Eileen ^{[1
]}

Wasylink, Suzanne ^{[1
]}

Repovs, Grega ^{[9
]}

Cole, Michael W. ^{[10
]}

Bednarski, Sarah ^{[1
]}

Krystal, John H. ^{[1
,6
]}

Bloch, Michael H. ^{[1
,4
]}

Li, Chiang-Shan R. ^{[1
,3
,7
]}

Pittenger, Christopher ^{[1
,2
,4
,5
,7
]}

机构：

[1] Yale Univ, Dept Psychiat, New Haven, CT 06519 USA

[2] Yale Univ, Dept Psychol, New Haven, CT 06519 USA

[3] Yale Univ, Dept Neurobiol, New Haven, CT 06519 USA

[4] Yale Univ, Ctr Child Study, New Haven, CT 06519 USA

[5] Yale Univ, Abraham Ribicoff Res Facil, New Haven, CT 06519 USA

[6] Yale Univ, NIAAA, Ctr Translat Neurosci Alcoholism, New Haven, CT 06519 USA

[7] Yale Univ, Interdept Neurosci Program, New Haven, CT 06519 USA

[8] Univ Zagreb, Univ Psychiat Hosp Vrapce, Zagreb 41000, Croatia

[9] Univ Ljubljana, Dept Psychol, Ljubljana, Slovenia

[10] Washington Univ, St Louis, MO USA

来源：

BIOLOGICAL PSYCHIATRY | 2014年 / 75卷 / 08期

关键词：

Basal ganglia; functional connectivity; global connectivity; obsessive-compulsive disorder; prefrontal cortex; resting-state fMRI; CEREBRAL GLUCOSE-METABOLISM; DEEP BRAIN-STIMULATION; SYMPTOM PROVOCATION; PREFRONTAL CORTEX; BASAL GANGLIA; BLOOD-FLOW; CONNECTIVITY; METAANALYSIS; ORGANIZATION; ANXIETY;

D O I：

10.1016/j.biopsych.2013.10.021

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Background: Obsessive-compulsive disorder (OCD) is associated with regional hyperactivity in cortico-striatal circuits. However, the large-scale patterns of abnormal neural connectivity remain uncharacterized. Resting-state functional connectivity studies have shown altered connectivity within the implicated circuitry, but they have used seed-driven approaches wherein a circuit of interest is defined a priori. This limits their ability to identify network abnormalities beyond the prevailing framework. This limitation is particularly problematic within the prefrontal cortex (PFC), which is large and heterogeneous and where a priori specification of seeds is therefore difficult. A hypothesis-neutral, data-driven approach to the analysis of connectivity is vital. Methods: We analyzed resting-state functional connectivity data collected at 3T in 27 OCD patients and 66 matched control subjects with a recently developed data-driven global brain connectivity (GBC) method, both within the PFC and across the whole brain. Results: We found clusters of decreased connectivity in the left lateral PFC in both whole-brain and PFC-restricted analyses. Increased GBC was found in the right putamen and left cerebellar cortex. Within regions of interest in the basal ganglia and thalamus, we identified increased GBC in dorsal striatum and anterior thalamus, which was reduced in patients on medication. The ventral striatum/nucleus accumbens exhibited decreased global connectivity but increased connectivity specifically with the ventral anterior cingulate cortex in subjects with OCD. Conclusions: These findings identify previously uncharacterized PFC and basal ganglia dysconnectivity in OCD and reveal differentially altered GBC in dorsal and ventral striatum. Results highlight complex disturbances in PFC networks, which could contribute to disrupted cortical-striatal-cerebellar circuits in OCD.

引用

页码：595 / 605

页数：11

共 81 条

[1]

fMRI of neuronal activation with symptom provocation in unmedicated patients with obsessive compulsive disorder [J].