Fungicidal activity of Cecropin A

被引：89

作者：

DeLucca, AJ ^{[1
]}

Bland, JM ^{[1
]}

Jacks, TJ ^{[1
]}

Grimm, C ^{[1
]}

Cleveland, TE ^{[1
]}

Walsh, TJ ^{[1
]}

机构：

[1] NCI,PEDIAT BRANCH,IMMUNOCOMPROMISED HOST SECT,NIH,BETHESDA,MD 20892

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1997年 / 41卷 / 02期

关键词：

D O I：

10.1128/AAC.41.2.481

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cecropin A (CA) fungicidal properties were explored. Nongerminated and germinated Aspergillus spp. and Fusarium spp. conidia were treated with CA. CA achieved complete lethality at less than or equal to 25 mu M (99 mu g/ml) for germinating, but not nongerminating, conidia of Aspergillus spp. CA achieved total lethality for nongerminated and germinating conidia of Fusarium spp at 1.5 mu M (6 mu g/ml). MIC and minimal lethal concentration assays in buffered RPMI medium gave similar results.

引用

页码：481 / 483

页数：3

共 36 条

[1] THE EMERGING ROLE OF FUSARIUM INFECTIONS IN PATIENTS WITH CANCER [J].

ANAISSIE, E ;

KANTARJIAN, H ;

RO, J ;

HOPFER, R ;

ROLSTON, K ;

FAINSTEIN, V ;

BODEY, G .

MEDICINE, 1988, 67 (02) :77-83

[2]

AUSWICK PKC, 1986, APPL MYCOLOGY FUSARI, P129

[3] ON THE PRIMARY STRUCTURES OF LYSOZYME, CECROPINS AND ATTACINS FROM HYALOPHORA-CECROPIA [J].

BOMAN, HG ;

FAYE, I ;

VONHOFSTEN, P ;

KOCKUM, K ;

LEE, JY ;

XANTHOPOULOS, KG ;

BENNICH, H ;

ENGSTROM, A ;

MERRIFIELD, RB ;

ANDREU, D .

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 1985, 9 (03) :551-558

[4]

BOMAN HG, 1981, TRENDS BIOCHEM SCI, V6, P306, DOI 10.1146/annurev.mi.41.100187.000535

[5] CHANNEL-FORMING PROPERTIES OF CECROPINS AND RELATED MODEL COMPOUNDS INCORPORATED INTO PLANAR LIPID-MEMBRANES [J].

CHRISTENSEN, B ;

FINK, J ;

MERRIFIELD, RB ;

MAUZERALL, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (14) :5072-5076

[6]

COHEN J, 1991, FUNGAL INFECT COMPRO, P118

[7] BINDING BETWEEN LIPOPOLYSACCHARIDE AND CECROPIN-A [J].

DELUCCA, AJ ;

JACKS, TJ ;

BROGDEN, KA .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 1995, 151 (02) :141-148

[8] N-acetylcysteine inhibits germination of conidia and growth of Aspergillus spp and Fusarium spp [J].

DeLucca, AJ ;

Walsh, TJ ;

Daigle, DJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (05) :1274-1276

[9]

DENNING DW, 1990, REV INFECT DIS, V12, P1147

[10] COMPARATIVE AND COLLABORATIVE EVALUATION OF STANDARDIZATION OF ANTIFUNGAL SUSCEPTIBILITY TESTING FOR FILAMENTOUS FUNGI [J].

ESPINELINGROFF, A ;

DAWSON, K ;

PFALLER, M ;

ANAISSIE, E ;

BRESLIN, B ;

DIXON, D ;

FOTHERGILL, A ;

PAETZNICK, V ;

PETER, J ;

RINALDI, M ;

WALSH, T .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (02) :314-319

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