Progress toward the structure and therapeutic use of the hairpin ribozyme

被引:43
作者
Earnshaw, DJ [1 ]
Gait, MJ [1 ]
机构
[1] MRC,MOL BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND
来源
ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT | 1997年 / 7卷 / 04期
关键词
D O I
10.1089/oli.1.1997.7.403
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The hairpin ribozyme is one of a number of small catalytic RNAs that are excellent paradigms for RNA structure-function analysis and have potential also as therapeutic agents. This review outlines current understanding of the structure of the hairpin ribozyme and its basis for catalytic activity. Included also is a discussion of the functional group requirements for cleavage and the first steps being taken to understanding its folding. Finally, recent developments are highlighted in engineering the hairpin ribozyme for intracellular use as a potential gene therapy agent.
引用
收藏
页码:403 / 411
页数:9
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