6-bromoflavone, a high affinity ligand for the central benzodiazepine receptors is a member of a family of active flavonoids

被引：51

作者：

Marder, M

Viola, H

Wasowski, C

Wolfman, C

Waterman, PG

Cassels, BK

Medina, JH

Paladini, AC

机构：

[1] UNIV BUENOS AIRES,FAC FARM & BIOQUIM,INST QUIM & FISICOQUIM BIOL,RA-1113 BUENOS AIRES,DF,ARGENTINA

[2] UNIV BUENOS AIRES,FAC MED,INST BIOL CELULAR,RA-1121 BUENOS AIRES,DF,ARGENTINA

[3] UNIV STRATHCLYDE,STRATHCLYDE INST DRUG RES,GLASGOW G1 1XW,LANARK,SCOTLAND

[4] UNIV STRATHCLYDE,DEPT PHARMACEUT SCI,GLASGOW G1 1XW,LANARK,SCOTLAND

[5] UNIV CHILE,FAC CIENCIAS,DEPT QUIM,SANTIAGO 1,CHILE

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 223卷 / 02期

关键词：

D O I：

10.1006/bbrc.1996.0903

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

6-Bromoflavone, obtained by bromination of flavanone, binds to central benzodiazepine receptors with a Ki = 70 nM and has a clear anxiolytic activity in mice, at 0.5 mg/kg, i.p. A survey of the structure/affinity relationship for those receptors in a series of natural and synthetic flavonoids is presented. (C) 1996 Academic Press, Inc.

引用

页码：384 / 389

页数：6

共 14 条

[1] H-1 AND C-13 ASSIGNMENTS FROM SENSITIVITY-ENHANCED DETECTION OF HETERONUCLEAR MULTIPLE-BOND CONNECTIVITY BY 2D MULTIPLE QUANTUM NMR [J].