Naive human umbilical cord matrix derived stem cells significantly attenuate growth of human breast cancer cells in vitro and in vivo

被引：99

作者：

Ayuzawa, Rie ^{[1
]}

Doi, Chiyo ^{[1
]}

Rachakatla, Raja Shekar ^{[1
]}

Pyle, Marla M. ^{[1
]}

Maurya, Dharmendra Kumar ^{[1
]}

Troyer, Deryl ^{[1
]}

Tamura, Masaaki ^{[1
]}

机构：

[1] Kansas State Univ, Coll Vet Med, Dept Anat & Physiol, Manhattan, KS 66506 USA

来源：

CANCER LETTERS | 2009年 / 280卷 / 01期

关键词：

Human umbilical cord matrix stem cells; Breast cancer; MDA; 231; cells; Xenografts; Colony assay; TUMOR STROMA; DELIVERY; TRANSPLANTATION; VEHICLES; THERAPY; ETHICS; MODEL;

D O I：

10.1016/j.canlet.2009.02.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The effect of un-engineered (naive) human umbilical cord matrix stem cells (hUCMSC) on the metastatic growth of MDA 231 xenografts in SCID mouse lung was examined. Three weekly IV injections of 5 x 10(5) hUCMSC significantly attenuated MDA 231 tumor growth as compared to the saline-injected control. IV injected hUCMSC were detected only within tumors or in close proximity to the tumors. This in vivo result was corroborated by multiple in vitro studies such as colony assay in soft agar and [H-3]-thymidine uptake. These results suggest that naive hUCMSC may be a useful tool for cancer cytotherapy. Published by Elsevier Ltd.

引用

页码：31 / 37

页数：7

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