Electric stimulation on human cortex suppresses fast cortical activity and epileptic spikes

被引：58

作者：

Kinoshita, M

Ikeda, A

Matsumoto, R

Begum, T

Usui, K

Yamamoto, J

Matsuhashi, M

Takayama, M

Mikuni, N

Takahashi, J

Miyamoto, S

Shibasaki, H

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Neurol, Sakyo Ku, Kyoto 6068507, Japan

[2] Kyoto Univ, Grad Sch Med, Dept Neurosurg, Sakyo Ku, Kyoto 6068507, Japan

[3] Kyoto Univ, Grad Sch Med, Human Brain Res Ctr, Sakyo Ku, Kyoto 6068507, Japan

来源：

EPILEPSIA | 2004年 / 45卷 / 07期

关键词：

epilepsy; electric stimulation;

D O I：

10.1111/j.0013-9580.2004.60203.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Purpose: To investigate underlying mechanisms and adequate parameters for electric cortical stimulation to inhibit epileptic focus in humans. Methods: A patient with intractable partial epilepsy had subdural electrodes implanted for preoperative evaluation. Cortical functional mapping was performed by using 50-Hz alternating square pulse of 0.3-ms duration, 1 to 7 mA, within 5 s. Spike frequency and electrocorticogram (ECoG) power spectra were compared before and after the stimulation when epileptic focus and distant area were stimulated. A similar comparison also was performed in low-frequency stimulation of 0.9 Hz applied for 15 min. Results: Interictal spikes were reduced after electric cortical stimulation of the epileptic area at a frequency of 50 Hz as well as 0.9 Hz, with concomitant decrease in the electrographic fast activities at 50-Hz stimulation. Conclusions: These data suggest that electric cortical stimulation at both high and low frequency has a suppressive effect on epileptic activities in human cortex, possibly through distinct mechanisms.

引用

页码：787 / 791

页数：5

共 18 条

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