Protein Delivery by Enteric Copolymer Nanoparticles

被引：13

作者：

Dupeyron, D. ^{[2
]}

Rieumont, J. ^{[3
]}

Gonzalez, M. ^{[4
]}

Castano, V. M. ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Ctr Fis Aplicada & Tecnol Avanzada, Santiago De Queretaro 76000, Queretaro, Mexico

[2] Univ La Habana, Inst Mat & Reactivos, Havana, Cuba

[3] Univ La Habana, Fac Quim, Havana, Cuba

[4] Ctr Ingn & Invest Quim, Ciudad Del La Habana, Cuba

来源：

JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY | 2009年 / 30卷 / 08期

关键词：

Enteric copolymer; PEG; protein nanoencapsulation; protein-matrix interaction; release profile; DRUG-DELIVERY; MICROSPHERES; RELEASE; THERAPY; PEPTIDE; SYSTEMS; PEG;

D O I：

10.1080/01932690802701739

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

The release profiles of bovine serum albumin nanoencapsulated into an enteric copolymer (methacrylic acid/ethyl acrylate blended with poly (ethylene glycol)) show an effective protection for this protein from the stringent pH gastric environment. The nanoParticles (nP) yield of about 90% and encapsulation efficiency of 77-78% indicate a successful control of the process. The experimental evidence leads to physical entanglements between PEG and the copolymer be considered as the driving factor to modulate the release.

引用

页码：1188 / 1194

页数：7

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