Drug resistance in veterinary helminths

被引：631

作者：

Wolstenholme, AJ ^{[1
]}

Fairweather, I

Prichard, R

von Samson-Himmelstjerna, G

Sangster, NC

机构：

[1] Univ Bath, Dept Biol & Biochem, Bath BA2 7AY, Avon, England

[2] Queens Univ Belfast, Sch Biol & Biochem, Ctr Med Biol, Belfast BT9 7BL, Antrim, North Ireland

[3] McGill Univ, Inst Parasitol, Ste Anne De Bellevue, PQ H9X 3V9, Canada

[4] Sch Vet Med, Inst Parasitol, D-30559 Hannover, Germany

[5] Univ Sydney, Fac Vet Sci, Sydney, NSW 2006, Australia

来源：

TRENDS IN PARASITOLOGY | 2004年 / 20卷 / 10期

关键词：

D O I：

10.1016/j.pt.2004.07.010

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

At present, there is no effective alternative to chemical control of parasitic helminths where livestock are grazed intensively. Resistance to anthelmintics has become a major problem in veterinary medicine, and threatens both agricultural income and animal welfare. The molecular and biochemical basis of this resistance is not well understood. The lack of reliable biological and molecular tests means that we are not able to follow the emergence and spread of resistance alleles and clinical resistance as well as we need. This review summarizes some of the recent findings on resistance mechanisms, puts forward some recommendations for limiting its impact and suggests some priorities for research in this area.

引用

页码：469 / 476

页数：8

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