Phenotypic changes in Langerhans' cells after infection with arboviruses: A role in the immune response to epidermally acquired viral infection?

被引：49

作者：

Johnston, LJ

Halliday, GM

King, NJC

机构：

[1] UNIV SYDNEY,DEPT PATHOL,SYDNEY,NSW 2006,AUSTRALIA

[2] UNIV SYDNEY,DEPT MED,SYDNEY,NSW 2006,AUSTRALIA

来源：

JOURNAL OF VIROLOGY | 1996年 / 70卷 / 07期

关键词：

D O I：

10.1128/JVI.70.7.4761-4766.1996

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The role of Langerhans cells (LC) in the initiation of an immune response to a viral infection remains unclear. In vivo epidermal infection with the arboviruses West Nile virus and Semliki Forest virus significantly increased the expression of major histocompatibility complex class II antigens, CD54, and CD80 on LC. Thus, during an epidermally acquired viral infection, local LC appear to mature to a phenotype approximating that of lymphoid dendritic cells, This change may be important in the activation of naive T cells acid the subsequent clearance of viral infection.

引用

页码：4761 / 4766

页数：6

共 25 条

[1] CYTOKINE MODULATION OF KERATINOCYTE CYTOKINES
ANSEL, J
PERRY, P
BROWN, J
DAMM, D
PHAN, T
HART, C
LUGER, T
HEFENEIDER, S
[J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1990, 94 (06) : S101 - S107
[2] PHORBOL-12-MYRISTATE-13-ACETATE-TREATED HUMAN KERATINOCYTES EXPRESS B7-LIKE MOLECULES THAT SERVE A COSTIMULATORY ROLE IN T-CELL ACTIVATION
AUGUSTIN, M
DIETRICH, A
NIEDNER, R
KAPP, A
SCHOPF, E
LEDBETTER, JA
BRADY, W
LINSLEY, PS
SIMON, JC
[J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1993, 100 (03) : 275 - 281
[3] FLOW-CYTOMETRY SORTING OF UNLABELED EPIDERMAL LANGERHANS CELLS USING FORWARD AND ORTHOGONAL LIGHT SCATTER PROPERTIES
CORDIER, G
DEZUTTERDAMBUYANT, C
LEFEBVRE, R
SCHMITT, D
[J]. JOURNAL OF IMMUNOLOGICAL METHODS, 1985, 79 (01) : 79 - 88
[4] CUMBERBATCH M, 1991, IMMUNOLOGY, V74, P414
[5] DOUGLAS MW, 1994, IMMUNOLOGY, V82, P561
[6] ADHESION OF T-LYMPHOBLASTS TO EPIDERMAL-KERATINOCYTES IS REGULATED BY INTERFERON-GAMMA AND IS MEDIATED BY INTERCELLULAR-ADHESION MOLECULE-1 (ICAM-1)
DUSTIN, ML
SINGER, KH
TUCK, DT
SPRINGER, TA
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 167 (04) : 1323 - 1340
[7] Griffin D. E., 1986, TOGAVIRIDAE FLAVIVIR, P209
[8] CYTOKINE GENE-EXPRESSION IN MURINE EPIDERMAL-CELL SUSPENSIONS - INTERLEUKIN-1-BETA AND MACROPHAGE INFLAMMATORY PROTEIN-1-ALPHA ARE SELECTIVELY EXPRESSED IN LANGERHANS CELLS BUT ARE DIFFERENTIALLY REGULATED IN CULTURE
HEUFLER, C
TOPAR, G
KOCH, F
TROCKENBACHER, B
KAMPGEN, E
ROMANI, N
SCHULER, G
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (04) : 1221 - 1226
[9] EFFECT OF HERPES-SIMPLEX VIRUS TYPE-1 AND TYPE-2 ON SURFACE EXPRESSION OF CLASS-I MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS ON INFECTED-CELLS
JENNINGS, SR
RICE, PL
KLOSZEWSKI, ED
ANDERSON, RW
THOMPSON, DL
TEVETHIA, SS
[J]. JOURNAL OF VIROLOGY, 1985, 56 (03) : 757 - 766
[10] INTERFERON-INDEPENDENT INCREASES IN CLASS-I MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGEN EXPRESSION FOLLOW FLAVIVIRUS INFECTION
KING, NJC
KESSON, AM
[J]. JOURNAL OF GENERAL VIROLOGY, 1988, 69 : 2535 - 2543

← 1 2 3 →