Expeditious synthesis of tri-substituted cyclopentane derivatives

被引：13

作者：

Desai, RC ^{[1
]}

Cicala, P ^{[1
]}

Meurer, LC ^{[1
]}

Finke, PE ^{[1
]}

机构：

[1] Merck Res Lab, Dept Med Chem, Rahway, NJ 07065 USA

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 26期

关键词：

D O I：

10.1016/S0040-4039(02)00901-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient preparation of the cyclopentane scaffold 2. a key precursor to the potent human NK1 antagonist 1 having three contiguous chiral centers is described. (C) 2002 Published by Elsevier Science Ltd.

引用

页码：4569 / 4570

页数：2

共 7 条

[1] ATTEMPTS TO PREPARE NEW AROMATIC SYSTEMS .1. CYCLOPENTINDENE - PHENYLCYCLOPENTANECARBOXYLIC ACIDS, AND DERIVED KETONES [J].

BAKER, W ;

LEEDS, WG .

JOURNAL OF THE CHEMICAL SOCIETY, 1948, (JUL) :974-980

[2]

CARRERA GM, 1994, SYNLETT, P93

[3] Structural optimization affording 2-(R)-(1-(R)-3,5-bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a potent, orally active, long-acting morpholine acetal human NK-1 receptor antagonist [J].

Hale, JJ ;

Mills, SG ;

MacCoss, M ;

Finke, PE ;

Cascieri, MA ;

Sadowski, S ;

Ber, E ;

Chicchi, GG ;

Kurtz, M ;

Metzger, J ;

Eiermann, G ;

Tsou, NN ;

Tattersall, FD ;

Rupniak, NMJ ;

Williams, AR ;

Rycroft, W ;

Hargreaves, R ;

MacIntyre, DE .

JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (23) :4607-4614

[4]

MEURER LC, 2000, AM CHEM SOC 219 NAT

[5]

QUATARA L, 1998, NEUROPEPTIDES, V32, P1

[6] Discovery of the anti-depressant and anti-emetic efficacy of substance P receptor (NK1) antagonists [J].

Rupniak, NMJ ;

Kramer, MS .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1999, 20 (12) :485-490

[7] POOLS, PARLAYS, AND POINT SPREADS - A SOCIOLOGICAL CONSIDERATION OF THE LEGALIZATION OF SPORTS GAMBLING [J].

SMITH, GJ .

SOCIOLOGY OF SPORT JOURNAL, 1990, 7 (03) :271-286

← 1 →