Psychobiology and molecular genetics of resilience

被引：823

作者：

Feder, Adriana ^{[1
]}

Nestler, Eric J. ^{[1
,2
,3
]}

Charney, Dennis S. ^{[1
,2
,3
]}

机构：

[1] Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA

[2] Mt Sinai Sch Med, Dept Neurosci, New York, NY 10029 USA

[3] Mt Sinai Sch Med, Dept Pharmacol & Syst Therapeut, New York, NY 10029 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2009年 / 10卷 / 06期

关键词：

STRESSFUL LIFE EVENTS; METHYLTRANSFERASE VAL(158)MET GENOTYPE; TRANSPORTER 5-HTTLPR GENOTYPE; NEUROPEPTIDE-Y CONCENTRATIONS; EMOTION PERCEPTION; POSITIVE EMOTIONS; NUCLEUS-ACCUMBENS; NEURAL MECHANISMS; BRAIN ACTIVATION; GLUCOCORTICOID-RECEPTOR;

D O I：

10.1038/nrn2649

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Every individual experiences stressful life events. In some cases acute or chronic stress leads to depression and other psychiatric disorders, but most people are resilient to such effects. Recent research has begun to identify the environmental, genetic, epigenetic and neural mechanisms that underlie resilience, and has shown that resilience is mediated by adaptive changes in several neural circuits involving numerous neurotransmitter and molecular pathways. These changes shape the functioning of the neural circuits that regulate reward, fear, emotion reactivity and social behaviour, which together are thought to mediate successful coping with stress.

引用

页码：446 / 457

页数：12

共 143 条

[1] Trauma, Resilience, and Recovery in a High-Risk African-American Population [J].

Alim, Tanya N. ;

Feder, Adriana ;

Graves, Ruth Elaine ;

Wang, Yanping ;

Weaver, James ;

Westphal, Maren ;

Alonso, Angelique ;

Aigbogun, Notalelomwan U. ;

Smith, Bruce W. ;

Doucette, John T. ;

Mellman, Thomas A. ;

Lawson, William B. ;

Charney, Dennis S. .

AMERICAN JOURNAL OF PSYCHIATRY, 2008, 165 (12) :1566-1575

[2] COLUMNAR ORGANIZATION IN THE MIDBRAIN PERIAQUEDUCTAL GRAY - MODULES FOR EMOTIONAL EXPRESSION [J].

BANDLER, R ;

SHIPLEY, MT .

TRENDS IN NEUROSCIENCES, 1994, 17 (09) :379-389

[3]

Bast T, 2007, REV NEUROSCIENCE, V18, P253

[4] Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress [J].

Berton, O ;

McClung, CA ;

DiLeone, RJ ;

Krishnan, V ;

Renthal, W ;

Russo, SJ ;

Graham, D ;

Tsankova, NM ;

Bolanos, CA ;

Rios, M ;

Monteggia, LM ;

Self, DW ;

Nestler, EJ .

SCIENCE, 2006, 311 (5762) :864-868

[5] Induction of ΔFosB in the periaqueductal gray by stress promotes active coping responses [J].

Berton, Olivier ;

Covington, Herbert E., III ;

Ebner, Karl ;

Tsankova, Nadia M. ;

Carle, Tiffany L. ;

Ulery, Paula ;

Bhonsle, Akshay ;

Barrot, Michel ;

Krishnan, Vaishnav ;

Singewald, Georg M. ;

Singewald, Nicolas ;

Birnbaum, Shari ;

Neve, Rachael L. ;

Nestler, Eric J. .

NEURON, 2007, 55 (02) :289-300

[6] Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults [J].

Binder, Elisabeth B. ;

Bradley, Rebekah G. ;

Liu, Wei ;

Epstein, Michael P. ;

Deveau, Todd C. ;

Mercer, Kristina B. ;

Tang, Yilang ;

Gillespie, Charles F. ;

Heim, Christine M. ;

Nemeroff, Charles B. ;

Schwartz, Ann C. ;

Cubells, Joseph F. ;

Ressler, Kerry J. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2008, 299 (11) :1291-1305

[7] Loss, trauma, and human resilience - Have we underestimated the human capacity to thrive after extremely aversive events? [J].

Bonanno, GA .

AMERICAN PSYCHOLOGIST, 2004, 59 (01) :20-28

[8]

Bowlby J., 1982, ATTACHMENT LOSS VOL, V1

[9] Influence of child abuse on adult depression - Moderation by the corticotropin-releasing hormone receptor gene [J].

Bradley, Rebekah G. ;

Binder, Elisabeth B. ;

Epstein, Michael P. ;

Tang, Yilang ;

Nair, Hemu P. ;

Liu, Wei ;

Gillespie, Charles F. ;

Berg, Tiina ;

Evces, Mark ;

Newport, D. Jeffrey ;

Stowe, Zachary N. ;

Heim, Christine M. ;

Nemeroff, Charles B. ;

Schwartz, Ann ;

Cubells, Joseph F. ;

Ressler, Kerry J. .

ARCHIVES OF GENERAL PSYCHIATRY, 2008, 65 (02) :190-200

[10] Amygdala volume in patients receiving chronic corticosteroid therapy [J].

Brown, E. Sherwood ;

Woolston, Dixie J. ;

Frol, Alan B. .

BIOLOGICAL PSYCHIATRY, 2008, 63 (07) :705-709

← 1 2 3 4 5 6 7 8 9 10 →