Stereocontrolled synthesis of a novel pharmacophore of the tubulin-depolymerizing marine natural product spongistatin

被引：43

作者：

Huang, H

Mao, C

Jan, ST

Uckun, FM ^{[1
]}

机构：

[1] Parker Hughes Inst, Drug Discovery Program, Dept Chem, St Paul, MN 55113 USA

[2] Parker Hughes Inst, Drug Discovery Program, Dept Biol Struct, St Paul, MN 55113 USA

[3] Parker Hughes Inst, Parker Hughes Canc Ctr, St Paul, MN 55113 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 11期

关键词：

D O I：

10.1016/S0040-4039(00)00054-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report here the synthesis and X-ray structure of a novel spiroketal pyran, SPIKET-P1, as a pharmocophore for the tubulin-depolymerizing marine natural product spongistatin 1. Following its retro-synthetic analysis, SPIKET-P1 was prepared using a versatile 11-step synthetic scheme in a stereocontrolled fashion. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1699 / 1702

页数：4

共 7 条

[1] THE SPONGISTATINS, POTENTLY CYTOTOXIC INHIBITORS OF TUBULIN POLYMERIZATION, BIND IN A DISTINCT REGION OF THE VINCA DOMAIN [J].