Inflammatory thoughts about glioma gene therapy

被引：24

作者：

Kielian, T ^{[1
]}

Hickey, WF ^{[1
]}

机构：

[1] Dartmouth Hitchcock Med Ctr, Dartmouth Med Sch, Dept Pathol, Lebanon, NH 03756 USA

来源：

NATURE MEDICINE | 1999年 / 5卷 / 11期

关键词：

D O I：

10.1038/15188

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gene therapy for treatment of glioma often involves delivery of herpes simplex virus-1 thymidine kinase gene. A new study shows that this approach can induce chronic inflammation, and raises important questions about current adenoviral-based clinical trials (pages 1256–1263).

引用

页码：1237 / 1238

页数：2

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