The impact of body mass index on outcome of patients undergoing percutaneous coronary intervention was assessed in 11,300 patients enrolled in the Evaluation of 7E3 for the Prevention of Ischemic Complications (EPIC), Evaluation of PTCA to Improve Long-term Outcome by cF7E3 Glycoprotein receptor blockade (EPILOG), Integrilin to Minimise Platelet Aggregation and Coronary Thrombosis-II (IMPACT 11). and Evaluation of Platelet IIb/IIIa Inhibitor for Stenting (EPISTENT) trials. Obesity was associated with a significantly reduced risk of myocardial infarction. death, need for urgent revascularization, and major or minor bleeding after percutuneous coronary intervention.