Visualization of cell death in vivo with the annexin A5 imaging protocol

被引：49

作者：

Reutelingsperger, CPM

Dumont, E

Thimister, PW

van Genderen, H

Kenis, H

van de Eijnde, S

Heidendal, G

Hofstra, L

机构：

[1] Univ Maastricht, Cardiovasc Res Inst, Dept Biochem, NL-6200 MD Maastricht, Netherlands

[2] Univ Maastricht, Cardiovasc Res Inst, Dept Cardiol, NL-6200 MD Maastricht, Netherlands

[3] Univ Maastricht, Univ Hosp Maastricht, Dept Nucl Med, NL-6200 MD Maastricht, Netherlands

[4] Univ Maastricht, Cardiovasc Res Inst, Dept Mol Cell Biol, NL-6200 MD Maastricht, Netherlands

来源：

JOURNAL OF IMMUNOLOGICAL METHODS | 2002年 / 265卷 / 1-2期

关键词：

visualization of cell death; annexin A5 imaging protocol; phosphatidylserine;

D O I：

10.1016/S0022-1759(02)00075-3

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Annexin A5 binds to phosphatidylserine (PS), which is one of the "eat me" signals at the surface of the apoptotic cell. This property has been the driving force for the research of annexin A5 as a probe to measure apoptosis in vitro and in vivo. A non-invasive imaging protocol using annexin A5 has been developed and applied successfully to measure programmed cell death programmed cell death (PCD) in patients. This review highlights the aspects of this development and discusses clinical relevance, limitations and future perspectives of this approach of visualizing cell death. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：123 / 132

页数：10

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