A graphene quantum dot photodynamic therapy agent with high singlet oxygen generation

被引：1437

作者：

Ge, Jiechao ^{[1
]}

Lan, Minhuan ^{[1
]}

Zhou, Bingjiang ^{[1
]}

Liu, Weimin ^{[1
]}

Guo, Liang ^{[1
]}

Wang, Hui ^{[1
]}

Jia, Qingyan ^{[1
]}

Niu, Guangle ^{[1
]}

Huang, Xing ^{[1
]}

Zhou, Hangyue ^{[1
]}

Meng, Xiangmin ^{[1
]}

Wang, Pengfei ^{[1
]}

Lee, Chun-Sing ^{[2
,3
]}

Zhang, Wenjun ^{[2
,3
]}

Han, Xiaodong ^{[4
]}

机构：

[1] Chinese Acad Sci, TIPC, Key Lab Photochem Convers & Optoelectron Mat, Beijing 100190, Peoples R China

[2] City Univ Hong Kong, Ctr Super Diamond & Adv Films COSDAF, Hong Kong 999077, Hong Kong, Peoples R China

[3] City Univ Hong Kong, Dept Phys & Mat Sci, Hong Kong 999077, Hong Kong, Peoples R China

[4] Beijing Univ Technol, Inst Microstructure & Properties Adv Mat, Beijing 100124, Peoples R China

来源：

NATURE COMMUNICATIONS | 2014年 / 5卷

基金：

中国国家自然科学基金;

关键词：

EMERGENT NANOLIGHTS; CARBON NANOTUBES; CANCER-CELLS; PHOTOSENSITIZERS; NANOPARTICLES; SENSITIZERS;

D O I：

10.1038/ncomms5596

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Clinical applications of current photodynamic therapy (PDT) agents are often limited by their low singlet oxygen (O-1(2)) quantum yields, as well as by photobleaching and poor biocompatibility. Here we present a new PDT agent based on graphene quantum dots (GQDs) that can produce O-1(2) via a multistate sensitization process, resulting in a quantum yield of similar to 1.3, the highest reported for PDT agents. The GQDs also exhibit a broad absorption band spanning the UV region and the entire visible region and a strong deep-red emission. Through in vitro and in vivo studies, we demonstrate that GQDs can be used as PDT agents, simultaneously allowing imaging and providing a highly efficient cancer therapy. The present work may lead to a new generation of carbon-based nanomaterial PDT agents with overall performance superior to conventional agents in terms of O-1(2) quantum yield, water dispersibility, photo-and pH-stability, and biocompatibility.

引用

页数：8

共 44 条

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