Mice that are congenic for the char2 locus are susceptible to malaria

被引：19

作者：

Burt, RA ^{[1
]}

Marshall, VM ^{[1
]}

Wagglen, J ^{[1
]}

Rodda, FR ^{[1
]}

Senyschen, D ^{[1
]}

Baldwin, TM ^{[1
]}

Buckingham, LA ^{[1
]}

Foote, SJ ^{[1
]}

机构：

[1] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia

来源：

INFECTION AND IMMUNITY | 2002年 / 70卷 / 08期

关键词：

D O I：

10.1128/IAI.70.8.4750-4753.2002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A major advance has been made towards the positional cloning of char2 (a quantitative trait locus encoding resistance to Plasmodium chabaudi malaria). Mice congenic for the locus have been used to fine map the gene and to prove that char2 plays a significant role in the outcome of malarial infection, independently of other resistance loci.

引用

页码：4750 / 4753

页数：4

共 8 条

[1] Temporal expression of an H2-linked locus in host response to mouse malaria [J].

Burt, RA ;

Baldwin, TM ;

Marshall, VM ;

Foote, SJ .

IMMUNOGENETICS, 1999, 50 (5-6) :278-285

[2] Mouse loci for malaria-induced mortality and the control of parasitaemia [J].

Foote, SJ ;

Burt, RA ;

Baldwin, TM ;

Presente, A ;

Roberts, AW ;

Laural, YL ;

Lew, AM ;

Marshall, VM .

NATURE GENETICS, 1997, 17 (04) :380-381

[3] Genetic control of blood parasitaemia in mouse malaria maps to chromosome 8 [J].

Fortin, A ;

Belouchi, A ;

Tam, MF ;

Cardon, L ;

Skamene, E ;

Stevenson, MM ;

Gros, P .

NATURE GENETICS, 1997, 17 (04) :382-383

[4]

LANDER ES, 1989, GENETICS, V121, P185

[5] Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains [J].

Markel, P ;

Shu, P ;

Ebeling, C ;

Carlson, GA ;

Nagle, DL ;

Smutko, JS ;

Moore, KJ .

NATURE GENETICS, 1997, 17 (03) :280-284

[6]

SNELL GD, 1958, JNCI-J NATL CANCER I, V20, P787

[7] Speed congenics: a classic technique in the fast lane (relatively speaking) [J].

Wakeland, E ;

Morel, L ;

Achey, K ;

Yui, M ;

Longmate, J .

IMMUNOLOGY TODAY, 1997, 18 (10) :472-477

[8]

ZENG ZB, 1994, GENETICS, V136, P1457

← 1 →