Calcium dependence of neurotransmitter release

被引：7

作者：

Matthews, G

vonGersdorff, H

机构：

[1] Dept. of Neurobiology and Behavior, State University of New York, Stony Brook

[2] Abteilung Membranbiophysik, Max-Planck-Inst. fur B., Am Fassberg

来源：

SEMINARS IN THE NEUROSCIENCES | 1996年 / 8卷 / 05期

基金：

美国国家卫生研究院;

关键词：

calcium channels; exocytosis; synaptic transmission;

D O I：

10.1006/smns.1996.0040

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neurotransmitter is released from synaptic terminals by rapid and highly targeted fusion of synaptic vesicles with the presynaptic membrane. Several lines of evidence suggest that the trigger for vesicle fusion is the large increase in internal [Ca2+] (up to hundreds of micromolar) achieved within the submicroscopic domain of elevated calcium near open calcium channels. The rapid vise and fall of [Ca2+] in this microdomain, together with the fast kinetics of the calcium-triggered fusion machinery, account for the speed of synaptic exocytosis.

引用

页码：329 / 334

页数：6

共 43 条

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ADLER EM, 1991, J NEUROSCI, V11, P1496

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