Urinary excretion of aquaporin-2 in pathological states of water metabolism

被引:30
作者
Ishikawa, S [1 ]
机构
[1] Jichi Med Sch, Dept Med, Div Endocrinol & Metab, Minami Kawachi, Tochigi 3290498, Japan
关键词
arginine vasopressin; diabetes insipidus; hyponatraemia; impaired water excretion;
D O I
10.3109/07853890009011757
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aquaporin-2 (AQP-2) is an arginine vasopressin (AVP)-regulated water channel in renal collecting duct cells. Approximately 3% of AQP-2 in collecting duct cells is excreted into urine, Urinary excretion of AQP-2 varies widely in different physiological conditions, and it has a positive correlation with plasma AVP levels. Urinary excretion of AQP-2 was significantly increased by the single injection of AVP in patients with central diabetes insipidus. The urinary excretion of AQP-2 was one-eighth over in patients with central diabetes insipidus and three times greater in patients with impaired water excretion than that in normal subjects. In a hypertonic saline rest, the urinary excretion of AQP-2 promptly increased 6-12-fold in normal subjects, but remained low in patients with central diabetes insipidus. In addition, exaggerated urinary excretion of AQP-2 persisted after an acute water load in patients with impaired water excretion. These results indicate that urinary excretion of AQP-2 is a potent marker for the diagnosis of water metabolism disorders dependent on AVP.
引用
收藏
页码:90 / 93
页数:4
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