Frequent occurrence of CYP2D6*10 duplication allele in a Japanese population

被引：21

作者：

Mitsunaga, Y

Kubota, T

Ishiguro, A

Yamada, Y

Sasaki, H

Chiba, K

Iga, T

机构：

[1] Tokyo Univ Hosp, Fac Med, Dept Pharm, Bunkyo Ku, Tokyo 1138655, Japan

[2] SRL Inc, Ctr Mol Biol & Cytogenet, Tokyo, Japan

[3] Chiba Univ, Grad Sch Pharmaceut Sci, Dept Pharmacogenet, Lab Biochem Pharmacol & Toxicol, Chiba, Japan

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2002年 / 505卷 / 1-2期

关键词：

CYP2D6*10; duplication; Japanese; ultrarapid metabolizer;

D O I：

10.1016/S0027-5107(02)00122-7

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Allele-specific long-polymerase chain reaction (PCR), PCR-restriction fragment length polymorphism (RFLP) and haplotype analysis using XbaI and EcoRI were used to determine whether gene duplication of CYP2D6*10 exists in a Japanese lpopulation of 162 healthy subjects. Based on the results of PCR and haplotype analysis, the frequencies of CYP2D6*1X2, CYP2D6*2X2 and CYP2D6*10X2 in the Japanese population were estimated to be 0.3, 0.3 and 0.6%, respectively. The results suggest that duplicated alleles of CYP2D6*10 exist in the Japanese population and that it may be one of the factors affecting the capacity of Japanese to metabolize various CYP2D6 substrate drugs. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：83 / 85

页数：3

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