Biosynthesis of hyperforin in Hypericum perforatum

被引：110

作者：

Adam, P

Arigoni, D

Bacher, A

Eisenreich, W

机构：

[1] Tech Univ Munich, Lehrstuhl Organ Chem & Biochem, D-85747 Garching, Germany

[2] Swiss Fed Inst Technol, Organ Chem Lab, HCI, CH-8093 Zurich, Switzerland

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2002年 / 45卷 / 21期

关键词：

D O I：

10.1021/jm0209782

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cut sprouts of Hypericum perforatum were proffered solutions containing [1-C-13]glucose or [U-C-13(6)]glucose. Hyperforin was isolated and analyzed by quantitative NMR spectroscopy. The labeling patterns show that the biosynthesis of hyperforin involves five isoprenoid moieties, which are derived entirely or predominantly (> 98%) via the deoxyxylulose phosphate pathway. The phloroglucinol moiety is generated via a polyketide type mechanism.

引用

页码：4786 / 4793

页数：8

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