Evidence of a major gene effect for angiotensinogen among Nigerians

被引:8
作者
Guo, X
Rotimi, C
Cooper, R
Luke, A
Elston, RC
Ogunbiyi, O
Ward, R
机构
[1] Loyola Univ, Dept Epidemiol & Prevent Med, Stritch Sch Med, Ctr Genet Epidemiol, Maywood, IL 60153 USA
[2] Loyola Univ, Dept Epidemiol & Prevent Med, Stritch Sch Med, Maywood, IL 60153 USA
[3] Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA
[4] Univ Ibadan, Univ Coll HOsp, Ibadan, Nigeria
[5] Univ Oxford, Dept Biol Anthropol, Oxford, England
关键词
D O I
10.1046/j.1469-1809.1999.6340293.x
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
To dissect the genetic pathway of hypertension, we measured angiotensinogen in 685 members of 186 families recruited from a rural community in southwest Nigeria. Commingling and segregation analyses were carried out. A mixture of two and/or three distributions fits the data significantly better than a single distribution in commingling analysis, suggesting a major gene effect. Segregation analysis confirmed that a recessive major gene model for low values of angiotensinogen provides the best fit to the data and about 13% of the variance was due to the recessive gene segregation.
引用
收藏
页码:293 / 300
页数:8
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