Towards novel biolabels: synthesis of a tagged highly fluorescent Schiff-base aluminium complex

被引：23

作者：

Briggs, MSJ

Fossey, JS

Richards, CJ

Scott, B

Whateley, J

机构：

[1] Amersham Pharmacia Biotech, Cardiff Labs, Cardiff CF14 7YT, S Glam, Wales

[2] Cardiff Univ, Dept Chem, Cardiff CF10 3TB, S Glam, Wales

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 29期

关键词：

D O I：

10.1016/S0040-4039(02)00953-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Starting from 3-(4-hydroxyphenyl)propanoic acid, formylation ortho to the phenol and condensation with ortho-aminophenol gave a novel functionalised Schiff-base ligand. Formation of the N-hydroxysuccinimidyl ester and non-aqueous complexation with AlEt2Cl gave a novel fluorescent biolabel displaying a Stokes shift of 100 nm. The efficacy of the new system was demonstrated by its attachment to rabbit IgG. (C) 2002 Elsevier Science Ltd. All rights reserved.

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收藏

页码：5169 / 5171

页数：3

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