Ecological effects of pharmaceuticals in aquatic systems-impacts through behavioural alterations

被引:350
作者
Brodin, Tomas [1 ]
Piovano, Susanna [3 ,4 ]
Fick, Jerker [2 ]
Klaminder, Jonatan [1 ]
Heynen, Martina [1 ]
Jonsson, Micael [1 ]
机构
[1] Umea Univ, Dept Ecol & Environm Sci, S-90187 Umea, Sweden
[2] Umea Univ, Dept Chem, S-90187 Umea, Sweden
[3] Univ S Pacific, Sch Biol & Chem Sci, Suva, Fiji
[4] Univ Turin, Dept Life Sci & Syst Biol, I-10124 Turin, Italy
关键词
benzodiazepines; bioconcentration; contaminants; behaviour; ecological effects; Perca fluviatilis; GENE-EXPRESSION; ENVIRONMENTAL RISK; FATHEAD MINNOW; FISH; FLUOXETINE; SEROTONIN; WATER; EXPOSURE; AGGRESSION; RESPONSES;
D O I
10.1098/rstb.2013.0580
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The study of animal behaviour is important for both ecology and ecotoxicology, yet research in these two fields is currently developing independently. Here, we synthesize the available knowledge on drug-induced behavioural alterations in fish, discuss potential ecological consequences and report results from an experiment in which we quantify both uptake and behavioural impact of a psychiatric drug on a predatory fish (Perca fluviatilis) and its invertebrate prey (Coenagrion hastulatum). We show that perch became more active while damselfly behaviour was unaffected, illustrating that behavioural effects of pharmaceuticals can differ between species. Furthermore, we demonstrate that prey consumption can be an important exposure route as on average 46% of the pharmaceutical in ingested prey accumulated in the predator. This suggests that investigations of exposure through bioconcentration, where trophic interactions and subsequent bioaccumulation of exposed individuals are ignored, underestimate exposure. Wildlife may therefore be exposed to higher levels of behaviourally altering pharmaceuticals than predictions based on commonly used exposure assays and pharmaceutical concentrations found in environmental monitoring programmes.
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页数:10
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共 100 条
[1]   Medicines, shaken and stirred: a critical review on the ecotoxicology of pharmaceutical mixtures [J].
Backhaus, Thomas .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2014, 369 (1656)
[2]   Energy and nutrient fluxes from rivers and streams into terrestrial food webs [J].
Ballinger, A ;
Lake, PS .
MARINE AND FRESHWATER RESEARCH, 2006, 57 (01) :15-28
[3]   Quantifying the evidence for biodiversity effects on ecosystem functioning and services [J].
Balvanera, Patricia ;
Pfisterer, Andrea B. ;
Buchmann, Nina ;
He, Jing-Shen ;
Nakashizuka, Tohru ;
Raffaelli, David ;
Schmid, Bernhard .
ECOLOGY LETTERS, 2006, 9 (10) :1146-1156
[4]   Effects of fluoxetine on the swimming and behavioural responses of the Arabian killifish [J].
Barry, Michael J. .
ECOTOXICOLOGY, 2013, 22 (02) :425-432
[5]  
Bergman A, 2014, WHO WHO UNEP UN ENV
[6]   EFFECTS OF THE ANTIHISTAMINE DIPHENHYDRAMINE ON SELECTED AQUATIC ORGANISMS [J].
Berninger, Jason P. ;
Du, Bowen ;
Connors, Kristin A. ;
Eytcheson, Stephanie A. ;
Kolkmeier, Mark A. ;
Prosser, Krista N. ;
Valenti, Theodore W., Jr. ;
Chambliss, C. Kevin ;
Brooks, Bryan W. .
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 2011, 30 (09) :2065-2072
[7]   Effects of the antidepressant venlafaxine on fish brain serotonin and predation behavior [J].
Bisesi, Joseph H., Jr. ;
Bridges, William ;
Klaine, Stephen J. .
AQUATIC TOXICOLOGY, 2014, 148 :130-138
[8]   Short-term effects of neuroactive pharmaceutical drugs on a fish species: Biochemical and behavioural effects [J].
Brandao, F. P. ;
Rodrigues, S. ;
Castro, B. B. ;
Goncalves, F. ;
Antunes, S. C. ;
Nunes, B. .
AQUATIC TOXICOLOGY, 2013, 144 :218-229
[9]   Behavioural and life history effects of predator diet cues during ontogeny in damselfly larvae [J].
Brodin, T ;
Mikolajewski, DJ ;
Johansson, F .
OECOLOGIA, 2006, 148 (01) :162-169
[10]   Conflicting selection pressures on the growth/predation risk trade-off in a damselfly [J].
Brodin, T ;
Johansson, F .
ECOLOGY, 2004, 85 (11) :2927-2932