An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control

被引：1034

作者：

Clevers, Hans ^{[1
,2
]}

Loh, Kyle M. ^{[3
]}

Nusse, Roel ^{[3
]}

机构：

[1] Univ Med Ctr Utrecht, Royal Netherlands Acad Arts & Sci KNAW, Hubrecht Inst, NL-3584 CT Utrecht, Netherlands

[2] CancerGenomics Nl, NL-3584 CT Utrecht, Netherlands

[3] Stanford Univ, Howard Hughes Med Inst, Stanford Inst Stem Cell Biol & Regenerat Med, Dept Dev Biol, Stanford, CA 94305 USA

来源：

SCIENCE | 2014年 / 346卷 / 6205期

基金：

美国国家科学基金会;

关键词：

POSTNATAL MAMMARY-GLAND; LONG-TERM EXPANSION; IN-VITRO EXPANSION; WNT/BETA-CATENIN; SELF-RENEWAL; SMALL-INTESTINE; TUMOR-SUPPRESSOR; PLANARIAN REGENERATION; STEM/PROGENITOR CELLS; KIDNEY DEVELOPMENT;

D O I：

10.1126/science.1248012

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Stem cells fuel tissue development, renewal, and regeneration, and these activities are controlled by the local stem cell microenvironment, the "niche." Wnt signals emanating from the niche can act as self-renewal factors for stem cells in multiple mammalian tissues. Wnt proteins are lipid-modified, which constrains them to act as short-range cellular signals. The locality of Wnt signaling dictates that stem cells exiting the Wnt signaling domain differentiate, spatially delimiting the niche in certain tissues. In some instances, stem cells may act as or generate their own niche, enabling the self-organization of patterned tissues. In this Review, we discuss the various ways by which Wnt operates in stem cell control and, in doing so, identify an integral program for tissue renewal and regeneration.

引用

页码：54 / +

页数：8

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