Airway Remodeling in Chronic Obstructive Pulmonary Disease and Asthma: the Role of Matrix Metalloproteinase-9

被引：125

作者：

Grzela, Katarzyna ^{[1
]}

Litwiniuk, Malgorzata ^{[2
,3
]}

Zagorska, Wioletta ^{[1
]}

Grzela, Tomasz ^{[2
]}

机构：

[1] Med Univ Warsaw, Dept Paediat Pneumonol & Allergol, PL-02004 Warsaw, Poland

[2] Med Univ Warsaw, Dept Histol & Embryol, Chalubinskiego 5, PL-02004 Warsaw, Poland

[3] Potgrad Sch Mol Med, Warsaw, Poland

来源：

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS | 2016年 / 64卷 / 01期

关键词：

Asthma; Chronic obstructive pulmonary disease; COPD; MMP-9; Remodeling; ANGIOTENSIN-CONVERTING ENZYME; ABDOMINAL AORTIC-ANEURYSM; VENOUS LEG ULCERS; MATRIX METALLOPROTEINASES; IV COLLAGENASE; SMOOTH-MUSCLE; INHALED CORTICOSTEROIDS; BRONCHIAL EPITHELIUM; POTENTIAL ROLE; GROWTH-FACTOR;

D O I：

10.1007/s00005-015-0345-y

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Chronic obstructive pulmonary disease (COPD) and asthma are both associated with airflow restriction and progressive remodeling, which affect the respiratory tract. Among various biological factors involved in the pathomechanisms of both diseases, proteolytic enzymes-matrix metalloproteinases (MMPs)-play an important role, especially MMP-9. In this review, the authors discuss the current topics of research concerning the possible role of MMP-9 in both mentioned diseases. They include the analysis of protein levels, nucleotide polymorphisms of MMP-9 gene and their possible correlation with asthma and COPD. Finally, the authors refer to the studies on MMP-9 inhibition as a new perspective for increasing the effectiveness of treatment in asthma and COPD.

引用

页码：47 / 55

页数：9

共 88 条

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Mast cell-fibroblast interactions induce matrix metalloproteinase-9 release from fibroblasts: Role for IgE-mediated mast cell activation [J].