Autologous renal cell cancer vaccines using heat shock protein-peptide complexes

被引：17

作者：

Aalamian, Maryam

Fuchs, Ephraim

Gupta, Renu

Levey, Daniel L. ^{[1
]}

机构：

[1] Antigen Inc, Lexington, MA 02421 USA

[2] Johns Hopkins Univ Hosp, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA

来源：

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS | 2006年 / 24卷 / 05期

关键词：

heat shock protein; autologous; renal cell carcinoma;

D O I：

10.1016/j.urolonc.2005.08.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Investigations into the role of heat shock proteins (HSPs) in immune response have progressed well into a third decade, and indications of their use for the treatment of renal cell carcinoma (RCC) in the adjuvant setting will be revealed in the near future when a randomized phase III clinical trial is completed. Additional ongoing and planned randomized clinical trials will test the efficacy of HSP-based vaccines in more advanced stages of RCC. This review describes the compelling scientific rationale behind testing HSPs in RCC against the backdrop of other immunotherapeutic approaches in this indication. (c) 2006 Elsevier Inc. All rights reserved.

引用

收藏

页码：425 / 433

页数：9

相关论文

共 98 条

[1] HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine [J].

Asea, A ;

Kraeft, SK ;

Kurt-Jones, EA ;

Stevenson, MA ;

Chen, LB ;

Finberg, RW ;

Koo, GC ;

Calderwood, SK .

NATURE MEDICINE, 2000, 6 (04) :435-442

[2] IL-2 in combination with IFN-α and 5-FU versus tamoxifen in metastatic renal cell carcinoma:: long-term results of a controlled randomized clinical trial [J].

Atzpodien, J ;

Kirchner, H ;

Illiger, HJ ;

Metzner, B ;

Ukena, D ;

Schott, H ;

Funke, PJ ;

Gramatzki, M ;

von Jürgensom, S ;

Wandert, T ;

Patzelt, T ;

Reitz, M .

BRITISH JOURNAL OF CANCER, 2001, 85 (08) :1130-1136

[3] Interleukin-2- and interferon alfa-2a-based immunochemotherapy in advanced renal cell carcinoma:: A prospectively German cooperative renal randomized trial of the carcinoma chemoimmunotherapy group (DGCIN) [J].

Atzpodien, J ;

Kirchner, H ;

Jonas, U ;

Bergmann, L ;

Schott, H ;

Heynemann, H ;

Fornara, P ;

Loening, SA ;

Roigas, J ;

Müller, SC ;

Bodenstein, H ;

Pomer, S ;

Metzner, B ;

Rebmann, U ;

Oberneder, R ;

Siebels, M ;

Wandert, T ;

Puchberger, T ;

Reitz, M .

JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (07) :1188-1194

[4] INTERLEUKIN-2 IN COMBINATION WITH INTERFERON-ALPHA AND 5-FLUOROURACIL FOR METASTATIC RENAL-CELL CANCER [J].

ATZPODIEN, J ;

KIRCHNER, H ;

HANNINEN, EL ;

DECKERT, M ;

FENNER, M ;

POLIWODA, H .

EUROPEAN JOURNAL OF CANCER, 1993, 29A :S6-S8

[5] Dendritic cell-tumor cell hybrid vaccination for metastatic cancer [J].

Barbuto, JAM ;

Ensina, LFC ;

Neves, AR ;

Bergami-Santos, PC ;

Leite, KRM ;

Marques, R ;

Costa, F ;

Martins, SC ;

Camara-Lopes, LH ;

Buzaid, AC .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2004, 53 (12) :1111-1118

[6] Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-κB pathway [J].

Basu, S ;

Binder, RJ ;

Suto, R ;

Anderson, KM ;

Srivastava, PK .

INTERNATIONAL IMMUNOLOGY, 2000, 12 (11) :1539-1546

[7] Vaccination of metastatic melanoma patients with autologous tumor-derived heat shock protein gp96-peptide complexes:: Clinical and immunologic findings [J].

Belli, F ;

Testori, A ;

Rivoltini, L ;

Maio, M ;

Andreola, G ;

Sertoli, MR ;

Gallino, G ;

Piris, A ;

Cattelan, A ;

Lazzari, I ;

Carrabba, M ;

Scita, G ;

Santantonio, C ;

Pilla, L ;

Tragni, G ;

Lombardo, C ;

Arienti, F ;

Marchianò, A ;

Queirolo, P ;

Bertolini, F ;

Cova, A ;

Lamaj, E ;

Ascani, L ;

Camerini, R ;

Corsi, M ;

Cascinelli, N ;

Lewis, JJ ;

Srivastava, P ;

Parmiani, G .

JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (20) :4169-4180

[8] Cutting edge:: Heat shock protein gp96 induces maturation and migration of CD11c+ cells in vivo [J].

Binder, RJ ;

Anderson, KM ;

Basu, S ;

Srivastava, PK .

JOURNAL OF IMMUNOLOGY, 2000, 165 (11) :6029-6035

[9] Peptides chaperoned by heat-shock proteins are a necessary and sufficient source of antigen in the cross-priming of CD8+ T cells [J].

Binder, RJ ;

Srivastava, PK .

NATURE IMMUNOLOGY, 2005, 6 (06) :593-599

[10] Essential role of CD91 in re-presentation of gp96-chaperoned peptides [J].

Binder, RJ ;

Srivastava, PK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (16) :6128-6133

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