Hydrogel beads based on amidated pectins for colon-specific drug delivery: The role of chitosan in modifying drug release

被引：131

作者：

Munjeri, O ^{[1
]}

Collett, JH ^{[1
]}

Fell, JT ^{[1
]}

机构：

[1] UNIV MANCHESTER,DEPT PHARM,MANCHESTER M13 9PL,LANCS,ENGLAND

来源：

JOURNAL OF CONTROLLED RELEASE | 1997年 / 46卷 / 03期

关键词：

hydrogel beads; drug delivery; chitosan; amidated pectins;

D O I：

10.1016/S0168-3659(96)01607-0

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A multiparticulate system with the potential for site-specific delivery to the colon has been investigated. Gelation of droplets of amidated pectin solutions in the presence of calcium is the basis of the method of preparation. Two drugs, indomethacin and sulphamethoxazole were successfully incorporated into the beads. Drug release from the beads was a function of media pH and drug loading. In simulated gastric and small intestinal conditions, drug release was greater with the more soluble sulphamethoxazole, but release of both drugs could be reduced to satisfactory levels by the formation of a chitosan polyelectrolyte complex around the beads. All the preparations released drug in simulated colonic conditions within 135 min.

引用

页码：273 / 278

页数：6

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