Heart rate at the onset of muscle contraction and during passive muscle stretch in humans: a role for mechanoreceptors

被引:155
作者
Gladwell, VF [1 ]
Coote, JH
机构
[1] Univ Essex, Ctr Sport & Exercise Sci Biol Sci, Colchester CO4 3SQ, Essex, England
[2] Univ Birmingham, Sch Med, Dept Physiol, Birmingham B15 2TT, W Midlands, England
来源
JOURNAL OF PHYSIOLOGY-LONDON | 2002年 / 540卷 / 03期
关键词
D O I
10.1113/jphysiol.2001.013486
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Previous evidence suggests that the heart rate (HR) increase observed with isometric exercise is dependent on different afferent mechanisms to those eliciting the increase in blood pressure (BP). Central command and muscle metaboreceptors have been shown to contribute to this differential effect. However, in experimental animals passive stretch of the hindlimb increases HR suggesting that small fibre mechanoreceptors could also have a role. This has not been previously shown in humans and was investigated in this study. Healthy human volunteers were instrumented to record BP, ECG, respiration, EMG of rectus femoris and gastrocnemius and contraction force of triceps surae. Voluntary isometric contraction of triceps surae elicited a significant HR change in the first three respiratory cycles at 40% of maximum voluntary contraction whereas BP did not change significantly until after 30 s. This suggests that different mechanisms are involved in the initiation of the cardiovascular changes. Sustained passive stretch of triceps surae for 1 min, by dorsiflexion of the foot, caused a significant (P < 0.05) increase in HR (5 +/- 2.6 beats min(-1)) with no significant change in BP. A time domain measure of cardiac vagal activity was reduced significantly during passive stretch from 69.7 +/- 12.9 to 49.6 +/- 8.9 ms. Rapid rhythmic passive stretch (0.5 Hz for 1 min) was without significant effect suggesting that large muscle proprioreceptors are not involved. We conclude that in man small fibre muscle mechanoreceptors responding to stretch, inhibit cardiac vagal activity and thus increase HR. These afferents could contribute to the initial cardiac acceleration in response to muscle contraction.
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页码:1095 / 1102
页数:8
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