Severe pneumonia due to cytomegalovirus in chronic obstructive pulmonary disease

被引：3

作者：

Bosc, C. ^{[1
]}

Clement, M. ^{[2
]}

Deroux, A. ^{[1
,2
]}

Mammar, A. ^{[1
]}

Pison, C. ^{[1
]}

Camara, B. ^{[1
]}

机构：

[1] CHU Grenoble, Hop Albert Michallon, Clin Univ Pneumol, F-38043 Grenoble 09, France

[2] Ctr Hosp Chambery, Serv Pneumol & Oncol Thorac, F-73000 Chambery, France

来源：

REVUE DES MALADIES RESPIRATOIRES | 2014年 / 31卷 / 05期

关键词：

Cytomegalovirus; Chronic obstructive pulmonary disease; Pneumonia; Immunocompetence; Inflammation; TNF-alpha; NECROSIS-FACTOR-ALPHA; IMMUNOCOMPETENT PATIENTS; REACTIVATION; INFECTION; LUNGS;

D O I：

10.1016/j.rmr.2013.09.013

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

100201 [内科学];

摘要：

Severe pneumonia due to cytomegalovirus in chronic obstructive pulmonary disease. Introduction. - We describe two cases of immunocompetent patients with chronic obstructive pulmonary disease (COPD) who developed severe cytomegalovirus (CMV) pneumonia. The clinical and radiological context and CMV replication in broncho-alveolar lavage suggested a diagnosis of CMV pneumonia. Case histories. - We report two cases in patients with moderate chronic obstructive pulmonary disease not treated with long-term steroid therapy who developed bilateral pneumonia with hypoxaemia. The only pathogen identified was CMV with replication of the virus in the broncho-alveolar lavage. Investigation failed to detect any associated immune deficiency. Conclusion. - Severe cytomegalovirus pneumonia could be encouraged by the existence of chronic obstructive pulmonary disease due to local inflammatory changes. (C) 2013 Published by Elsevier Masson SAS on behalf of SPLF.

引用

页码：435 / 438

页数：4

共 13 条

[1]

LUNGS ARE A MAJOR ORGAN SITE OF CYTOMEGALOVIRUS LATENCY AND RECURRENCE [J].

BALTHESEN, M ;

MESSERLE, M ;

REDDEHASE, MJ .

JOURNAL OF VIROLOGY, 1993, 67 (09) :5360-5366

[2]

Lipopolysaccharide, tumor necrosis factor alpha, or interleukin-1β triggers reactivation of latent cytomegalovirus in immunocompetent mice [J].

Cook, Charles H. ;

Trgovcich, Joanne ;

Zimmerman, Peter D. ;

Zhang, Yingxue ;

Sedmak, Daniel D. .

JOURNAL OF VIROLOGY, 2006, 80 (18) :9151-9158

[3]

Cytomegalovirus reactivation in critically ill immunocompetent hosts: A decade of progress and remaining challenges [J].

Cook, Charles H. ;

Trgovcich, Joanne .

ANTIVIRAL RESEARCH, 2011, 90 (03) :151-159

[4]

Severe cytomegalovirus (CMV) community-acquired pneumonia (CAP) in a nonimmunocompromised host [J].

Cunha, Burke A. ;

Pherez, Francisco ;

Walls, Nicole .

HEART & LUNG, 2009, 38 (03) :243-248

[5]

Severe cytomegalovirus infection in immunocompetent patients [J].

Eddleston, M ;

Peacock, S ;

Juniper, M ;

Warrell, DA .

CLINICAL INFECTIOUS DISEASES, 1997, 24 (01) :52-56

[6]

Cytomegalovirus pneumonia in immunocompetent host: Case report and literature review [J].

Grilli, Elisabetta ;

Galati, Vincenzo ;

Bordi, Licia ;

Taglietti, Fabrizio ;

Petrosillo, Nicola .

JOURNAL OF CLINICAL VIROLOGY, 2012, 55 (04) :356-359

[7]

International Consensus Guidelines on the Management of Cytomegalovirus in Solid Organ Transplantation [J].

Kotton, Camille N. ;

Kumar, Deepali ;

Caliendo, Angela M. ;

Asberg, Anders ;

Chou, Sunwen ;

Snydman, David R. ;

Allen, Upton ;

Humar, Atul .

TRANSPLANTATION, 2010, 89 (07) :779-795

[8]

Cytomegalovirus - An unexpected cause of ventilator-associated pneumonia [J].

Papazian, L ;

Fraisse, A ;

Garbe, L ;

Zandotti, C ;

Thomas, P ;

Saux, P ;

Perrin, G ;

Gouin, F .

ANESTHESIOLOGY, 1996, 84 (02) :280-287

[9]

Severe cytomegalovirus infection in apparently immunocompetent patients: a systematic review [J].

Rafailidis, Petros I. ;

Mourtzoukou, Eleni G. ;

Varbobitis, Ioannis C. ;

Falagas, Matthew E. .

VIROLOGY JOURNAL, 2008, 5 (1)

[10]

Role for tumor necrosis factor alpha in murine cytomegalovirus transcriptional reactivation in latently infected lungs [J].

Simon, CO ;

Seckert, CK ;

Dreis, D ;

Reddehase, MJ ;

Grzimek, NKA .

JOURNAL OF VIROLOGY, 2005, 79 (01) :326-340

← 1 2 →