A novel iNOS and COX-2 inhibitor from the aerial parts of Rodgersia podophylla

被引：10

作者：

Chin, Young-Won

Park, Eun Young

Seo, Seung-Yong

Yoon, Kee-Dong

Ahn, Mi-Jeong

Suh, Young-Ger

Kim, Sang Geon

Kim, Jinwoong ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

[2] Seoul Natl Univ, Res Inst Pharmaceut Sci, Seoul 151742, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 17期

关键词：

Rodgersia podophylla; rodgersinol; iNOS inhibitor; COX-2; inhibitor;

D O I：

10.1016/j.bmcl.2006.06.009

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

A novel compound, rodgersinol (1), was isolated from the aerial parts of Rodgersia podophylla and its structure was elucidated with various spectroscopic methods. Rodgersinol (1) exhibited the significant inhibitory effects on iNOS and COX-2 expressions in LPS-activated macrophages. (c) 2006 Elsevier Ltd. All rights reserved.

引用

收藏

页码：4600 / 4602

页数：3

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