Comparison of bronchopulmonary pharmacokinetics of clarithromycin and azithromycin

被引:140
作者
Patel, KB
Xuan, DW
Tessier, PR
Russomanno, JH
Quintiliani, R
Nightingale, CH
机构
[1] HARTFORD HOSP,OFF RES ADM,HARTFORD,CT 06102
[2] LONG ISL UNIV,ARNOLD & MARIE SCHWARTZ COLL PHARM,DEPT PHARM PRACTICE,BROOKLYN,NY 11201
[3] DEPT PHARM RES,HARTFORD,CT 06102
[4] LUNG PHYSICIANS CENT CONNECTICUT PC,HARTFORD,CT 06102
关键词
D O I
10.1128/AAC.40.10.2375
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The bronchopulmonary and plasma pharmacokinetics of clarithromycin (CLA; 500 mg given twice daily for nine doses) or azithromycin (AZ; 500 mg for the first dose and then 250 mg once daily for four doses) were assessed in 41 healthy nonsmokers, Bronchoalveolar lavage was performed at 4, 8, 12, or 24 h after administration of the last dose. The concentrations (mean +/- standard deviation) of CLA, 14-hydroxyclarithromycin, and AZ were measured in plasma, epithelial lining fluid (ELF), and alveolar macrophage (AM) cells by high-performance liquid chromatography assay, The concentrations of CLA achieved in ELF were 34.02 +/- 5.16 mu g/ml at 4 h, 20.63 +/- 4.49 mu g/ml at 8 h, 23.01 +/- 11.9 mu g/ml at 12 h, and 4.17 +/- 0.29 mu g/ml at 24 h, whereas at the same time points AZ concentrations remained below the limit of assay sensitivity (0.01 mu g/ml) for all but two subjects, The concentrations of CLA in the AM cells were significantly higher than those of AZ at 8 h (703 +/- 235 and 388 +/- 53 mu g/ml, respectively), However, the ratio of the concentration in AM cells/concentration in plasma was significantly higher for AZ than for CLA for all time points because of the lower concentration of AZ in plasma, These results indicate that while AZ has higher tissue concentration to plasma ratios, as shown by other investigators, the absolute concentrations of CLA in ARI cells and ELF are higher for up to 8 and 12 h, respectively, after administration of the last dose.
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页码:2375 / 2379
页数:5
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