Cyclophillin, TRIM5, and innate immunity to HIV-1

被引：70

作者：

Sokolskaja, Elena

Luban, Jeremy

机构：

[1] Columbia Univ, Dept Microbiol, New York, NY 10032 USA

[2] Columbia Univ, Dept Med, New York, NY 10032 USA

[3] Inst Biomed Res, CH-6500 Bellinzona, Switzerland

来源：

CURRENT OPINION IN MICROBIOLOGY | 2006年 / 9卷 / 04期

关键词：

D O I：

10.1016/j.mib.2006.06.011

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The peptidyl-prolyl isomerase cyclophilin A (CypA) binds a proline-rich loop on the surface of HIV-1 capsid (CA). This interaction increases HIV-1 infectivity in humans but promotes an anti-HIV-1 restriction activity in non-human primates. Efforts to understand these paradoxical effects of cyclophilin, along with more targeted approaches to uncover the genetic basis for HIV-1 restriction, led to the discovery of TRIM5 (tripartite motif protein 5), a CA-specific receptor for the retroviral core. The ensuing TRIM5 publication flurry established a paradigm of innate immunity in which the protein lattice of an invading retroviral core, rather than double-stranded RNA or lipopolysaccharide, is recognized by a multimeric, cytoplasmic receptor. CypA modulates HIV-1 virion core detection by this class of innate pattern recognition molecule, apparently by inducing subtle shifts in CA conformation.

引用

收藏

页码：404 / 408

页数：5

相关论文

共 70 条

[1] SIV/HIV-1 hybrid virus expressing the reverse transcriptase gene of HIV-1 remains sensitive to HIV-1-specific reverse transcriptase inhibitors after passage in rhesus macaques [J].

Balzarini, J ;

DeClercq, E ;

Uberla, K .

JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, 1997, 15 (01) :1-4

[2] Cyclophilin A is required for TRIM5α-mediated resistance to HIV-1 in old world monkey cells [J].

Berthoux, L ;

Sebastian, S ;

Sokolskaja, E ;

Luban, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (41) :14849-14853

[3] Disruption of human TRIM5α antiviral activity by nonhuman primate orthologues [J].

Berthoux, L ;

Sebastian, S ;

Sayah, DM ;

Luban, J .

JOURNAL OF VIROLOGY, 2005, 79 (12) :7883-7888

[4] Lv1 inhibition of human immunodeficiency virus type 1 is counteracted by factors that stimulate synthesis or nuclear translocation of viral cDNA [J].

Berthoux, L ;

Sebastian, S ;

Sokolskaja, E ;

Luban, J .

JOURNAL OF VIROLOGY, 2004, 78 (21) :11739-11750

[5] Restriction of lentivirus in monkeys [J].

Besnier, C ;

Takeuchi, Y ;

Towers, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (18) :11920-11925

[6] Positional cloning of the mouse retrovirus restriction gene Fv1 [J].

Best, S ;

LeTissier, P ;

Towers, G ;

Stoye, JP .

NATURE, 1996, 382 (6594) :826-829

[7] Catalysis of cis/trans isomerization in native HIV-1 capsid by human cyclophilin A [J].

Bosco, DA ;

Eisenmesser, EZ ;

Pochapsky, S ;

Sundquist, WI ;

Kern, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (08) :5247-5252

[8] Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells [J].

Braaten, D ;

Luban, J .

EMBO JOURNAL, 2001, 20 (06) :1300-1309

[9] Cyclophilin A is required for an early step in the life cycle of human immunodeficiency virus type 1 before the initiation of reverse transcription [J].

Braaten, D ;

Franke, EK ;

Luban, J .

JOURNAL OF VIROLOGY, 1996, 70 (06) :3551-3560

[10] Cyclosporine A-resistant human immunodeficiency virus type 1 mutants demonstrate that Gag encodes the functional target of cyclophilin A [J].

Braaten, D ;

Aberham, C ;

Franke, EK ;

Yin, L ;

Phares, W ;

Luban, J .

JOURNAL OF VIROLOGY, 1996, 70 (08) :5170-5176

← 1 2 3 4 5 6 7 →