Drug-induced neurobehavioral plasticity: the role of environmental context

被引：116

作者：

Badiani, A

Robinson, TE

机构：

[1] Univ Roma La Sapienza, Dept Human Physiol & Pharmacol, I-00185 Rome, Italy

[2] Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Program Neurosci, Ann Arbor, MI 48109 USA

来源：

BEHAVIOURAL PHARMACOLOGY | 2004年 / 15卷 / 5-6期

关键词：

environment; novelty; context; addiction; learning; stress; sensitization; psychostimulants; opioids; immediate early genes; dendrites; dendritic spines; plasticity;

D O I：

10.1097/00008877-200409000-00004

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Repeated administrations of addictive drugs produce long-lasting changes in brain and behavior. However, drug-induced neurobehavioral plasticity is not a mere function of the neuropharmacological actions of drugs, but the result of complex drug-environment interactions. In the present review we summarize results obtained in a series of studies using an animal model of drug-environment interaction, showing that environmental context and past drug history interact to modulate the effects of amphetamine, cocaine and morphine on behavior, gene expression and structural plasticity. These findings may help shed some light on the conditions necessary for addictive drugs to enduringly alter brain and behavior. (C) 2004 Lippincott Williams Wilkins.

引用

页码：327 / 339

页数：13

共 146 条

[1] NEW PERSPECTIVES IN BASAL FOREBRAIN ORGANIZATION OF SPECIAL RELEVANCE FOR NEUROPSYCHIATRIC DISORDERS - THE STRIATOPALLIDAL, AMYGDALOID, AND CORTICOPETAL COMPONENTS OF SUBSTANTIA INNOMINATA [J].