Is clinical tolerance realistic in the next decade?

被引：30

作者：

Ashton-Chess, Joanna ^{[1
]}

Brouard, Sophie ^{[1
]}

Soulillou, Jean-Paul ^{[1
]}

机构：

[1] CHU Hotel Dieu, INSERM, U643, F-44035 Nantes 01, France

来源：

TRANSPLANT INTERNATIONAL | 2006年 / 19卷 / 07期

关键词：

clinic; kidney transplantation; operational tolerance; tolerance;

D O I：

10.1111/j.1432-2277.2006.00339.x

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Tolerance to allografts would mean a better quality of life and prognosis for transplant patients. Despite the first descriptions of tolerance to alloantigens over 50 years ago, deliberately induced tolerance in the clinic on a wide scale remains a goal that is not quite in reach. However, much progress has been made in understanding tolerance in rodent models and in the few reports of induced or spontaneously occurring tolerance in humans. Here, we review this progress made in the quest to achieve clinical tolerance.

引用

页码：539 / 548

页数：10

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