Genome-wide expression profile of sporadic gastric cancers with microsatellite instability

被引：283

作者：

D'Errico, Mariarosaria ^{[1
]}

de Rinaldis, Emanuele ^{[2
]}

Blasi, Monica F. ^{[1
]}

Viti, Valentina ^{[2
]}

Falchetti, Mario ^{[3
]}

Calcagnile, Angelo ^{[1
]}

Sera, Francesco ^{[4
]}

Saieua, Calogero ^{[4
]}

Ottini, Laura ^{[3
]}

Palli, Domenico ^{[4
]}

Palombo, Fabio ^{[2
]}

Giuliani, Alessandro ^{[1
]}

Dogliotti, Eugenia ^{[1
]}

机构：

[1] Ist Super Sanita, Dept Environm & Primary Prevent, I-00161 Rome, Italy

[2] IRBM P Angeletti, Dept Oncol, Rome, Italy

[3] Univ Roma La Sapienza, Dept Expt Med, I-00161 Rome, Italy

[4] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, I-50139 Florence, Italy

来源：

EUROPEAN JOURNAL OF CANCER | 2009年 / 45卷 / 03期

关键词：

Microsatellite instability; Gastric cancer; Gene expression; DNA repair; DNA-REPAIR; COLON CANCERS; GENE; MUTATIONS; 5-FLUOROURACIL; DEFECTS; P53;

D O I：

10.1016/j.ejca.2008.10.032

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gastric cancers with mismatch repair (MMR) inactivation are characterised by microsatellite instability (MSI). In this study, the transcriptional profile of 38 gastric cancers with and without MSI was analysed. Unsupervised analysis showed that the immune and apoptotic gene networks efficiently discriminated these two cancer types. Hierarchical clustering analysis revealed numerous gene expression changes associated with the MSI phenotype. Amongst these, the p53-responsive genes maspin and 14-3-3 sigma were significantly more expressed in tumours with than without MSI. A tight immunosurveillance coupled with a functional p53 gene response is consistent with the better prognosis of MSI cancers. Frequent silencing of MLH1 and downregulation of MMR target genes, such as MRE11 and MBD4, characterised MSI tumours. The downregulation of SMUG1 was also a typical feature of these tumours. The DNA repair gene expression profile of gastric cancer with MSI is of relevance for therapy response. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：461 / 469

页数：9

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