β-glucan recognition by the innate immune system

被引：492

作者：

Goodridge, Helen S. ^{[1
]}

Wolf, Andrea J. ^{[1
]}

Underhill, David M. ^{[1
]}

机构：

[1] Cedars Sinai Med Ctr, Immunobiol Res Inst, Los Angeles, CA 90048 USA

来源：

IMMUNOLOGICAL REVIEWS | 2009年 / 230卷

关键词：

inflammation; pattern recognition receptors; fungal infections; macrophages; phagocytosis; signal transduction; NF-KAPPA-B; BINDING LECTIN SITE; CYTOSOLIC PHOSPHOLIPASE A(2); CANDIDA-ALBICANS YEAST; C-TYPE LECTIN; HOST-DEFENSE; ASPERGILLUS-FUMIGATUS; INFLAMMATORY RESPONSES; PNEUMOCYSTIS-CARINII; NEGATIVE REGULATION;

D O I：

10.1111/j.1600-065X.2009.00793.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

beta-glucans are recognized by the innate immune system. This recognition plays important roles in host defense and presents specific opportunities for clinical modulation of the host immune response. Neutrophils, macrophages, and dendritic cells among others express several receptors capable of recognizing beta-glucan in its various forms. This review explores what is currently known about beta-glucan recognition and how this recognition stimulates immune responses. Special emphasis is placed on Dectin-1, as we know the most about how this key beta-glucan receptor translates recognition into intracellular signaling, stimulates cellular responses, and participates in orchestrating the adaptive immune response.

引用

页码：38 / 50

页数：13

共 96 条

[1] Characterization of β-glucan recognition site on C-type lectin, dectin 1
Adachi, Y
Ishii, T
Ikeda, Y
Hoshino, A
Tamura, H
Aketagawa, J
Tanaka, S
Ohno, N
[J]. INFECTION AND IMMUNITY, 2004, 72 (07) : 4159 - 4171
[2] Differential high-affinity interaction of dectin-1 with natural or synthetic glucans is dependent upon primary structure and is influenced by polymer chain length and side-chain branching
Adams, Elizabeth L.
Rice, Peter J.
Graves, Bridget
Ensley, Harry E.
Yu, Hai
Brown, Gordon D.
Gordon, Siamon
Monteiro, Mario A.
Papp-Szabo, Erzsebet
Lowman, Douglas W.
Power, Trevor D.
Wempe, Michael F.
Williams, David L.
[J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2008, 325 (01) : 115 - 123
[3] Molecular definition of distinct cytoskeletal structures involved in complement- and Fc receptor-mediated phagocytosis in macrophages
Allen, LAH
Aderem, A
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (02) : 627 - 637
[4] Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive cDNA cloning
Ariizumi, K
Shen, GL
Shikano, S
Xu, S
Ritter, R
Kumamoto, T
Edelbaum, D
Morita, A
Bergstresser, PR
Takashima, A
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (26) : 20157 - 20167
[5] Candidiasis in interferon-γ knockout (IFN-γ-/-) mice
Balish, E
Wagner, RD
Vázquez-Torres, A
Pierson, C
Warner, T
[J]. JOURNAL OF INFECTIOUS DISEASES, 1998, 178 (02) : 478 - 487
[6] CD5-mediated negative regulation of antigen receptor-induced growth signals in B-1 B cells
Bikah, G
Carey, J
Ciallella, JR
Tarakhovsky, A
Bondada, S
[J]. SCIENCE, 1996, 274 (5294) : 1906 - 1909
[7] Blystone SD, 1999, ADV CELL MOL BIOL ME, V5, P103, DOI 10.1016/S1874-5172(99)80030-3
[8] THE ROLE OF EXTRACELLULAR-MATRIX PROTEINS IN THE CONTROL OF PHAGOCYTOSIS
BROWN, EJ
[J]. JOURNAL OF LEUKOCYTE BIOLOGY, 1986, 39 (05) : 579 - 591
[9] Dectin-1 is a major β-glucan receptor on macrophages
Brown, GD
Taylor, PR
Reid, DM
Willment, JA
Williams, DL
Martinez-Pomares, L
Wong, SYC
Gordon, S
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (03) : 407 - 412
[10] Dectin-1 mediates the biological effects of β-glucans
Brown, GD
Herre, J
Williams, DL
Willment, JA
Marshall, ASJ
Gordon, S
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (09) : 1119 - 1124

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