Initial clinical testing of a holographic non-invasive contact lens glucose sensor

Introduction: The purpose of the present study was to determine the effectiveness of a new holographic contact lens glucose sensor for the non-invasive monitoring of blood glucose. Methods: One fasting normal subject was given an oral challenge consisting of 44 g of glucose. The contact lens hologram signal and fingerstick blood glucose were measured over a 26-min period. Results: The contact lens hologram signal appeared to track blood glucose well. The contact lens was comfortable and well tolerated. Conclusion: The holographic contact lens glucose sensor shows promise as a non-invasive home glucose monitor.