Dendritic Ih normalizes temporal summation in hippocampal CA1 neurons

被引：510

作者：

Magee, JC ^{[1
]}

机构：

[1] Louisiana State Univ, Med Ctr, Ctr Neurosci, New Orleans, LA 70112 USA

来源：

NATURE NEUROSCIENCE | 1999年 / 2卷 / 06期

关键词：

D O I：

10.1038/9158

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Most mammalian central neurons receive synaptic input over complicated dendritic arbors. Therefore, timing of synaptic information should vary with synapse location. However, I report that temporal summation at CA1 pyramidal somata does not depend on the location of synaptic input. This spatial normalization of temporal integration requires a dendritic hyperpolarization-activated current (I-h). Shaping of synaptic activity by deactivating a nonuniform lh could counterbalance filtering by dendrites and effectively remove location-dependent variability in temporal integration, thus enhancing synchronization of neuronal populations and functional capabilities of the hippocampal CA1 region.

引用

页码：508 / 514

页数：7

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